Feline Eosinophilic Granuloma Complex

Prof. Andrew Leisewitz

BVSc, MMedVet(Med), PhD
Senior Lecturer
Department of Companion Animal Clinical Studies
Faculty of Veterinary Science

Lesions associated with Eosinophiic Granuloma Complex (EGC)

This condition is in fact not a single disease but rather the manifestation of an underlying cause that presents with a variable complex of skin lesions. It is not a specific diagnosis but rather representative of a cutaneous reaction pattern. The most common underlying condition is a hypersensitivity and the most common presenting lesions include indolent (rodent) ulcers; eosinophilic plaques and eosinophilic granulomas. (Fig 1-4)


Most authors recognise that this presentation is most likely a manifestation of feline allergic skin disease. Some alternative aetiologies have been suggested.

These include:

  • Insect bites (especially mosquito bites) – although most clinicians would see this as a separate disease entity.  (Fig 5)
  • Various infectious agents have been suggested based on the frequent presence of bacteria seen on cytology and histology. It should however be remembered that the ulcerated lesions are predisposed to secondary bacterial infection. In one study cytological evidence of infection was found in all cats examined and treatment with amoxicillin/clavulanate resulted in significant improvement in most cats after 21 days of use.

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